Журнал "Гастроэнтерология" Том 56, №3, 2022
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Biochemical indicators of gastric juice in patients with stenosis of the gastroduodenal zone of ulcer genesis
Авторы: N.V. Prolom, O.O. Halinskyi, A.M. Halinska
SI “Institute of Gastroenterology of the National Academy of Medical Sciences of Ukraine”, Dnipro, Ukraine
Рубрики: Гастроэнтерология
Разделы: Медицинские форумы
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The aim of the article: to determine pathological changes in the biochemical indicators of gastric juice in patients with stenosis of the gastric outlet of ulcer origin.
Materials and methods. The study was conducted in the Department of Digestive Surgery of the Institute of Gastroenterology of the National Academy of Medical Sciences of Ukraine in 24 patients with stenosis of the gastroduodenal zone of ulcer genesis. The control group consisted of 40 people. During esophagogastroduodenoscopy, gastric secretion was collected by aspiration into a graduated tube. The pH of gastric juice and the concentration of pepsin, glycoproteins, sialic acids, fucose, and hexosamines were determined. The acid-forming function was assessed by the pH of gastric juice according to Sheleketina’s method. The functional activity of the surface epithelial cells of the gastric mucosa was determined by the concentration of total glycoproteins in the gastric juice. The level of sialic acids was studied according to the method of I. Warren. The content of fucose was determined according to the method of L. Dische. The concentration of glycosaminoglycans was determined according to the method of R. Palmer.
Results. In patients with stenosis of the gastroduodenal zone, the average pH values were (3.76 ± 0.44), which increased by 50.0 % (p < 0.05) compared to the values of the control group but did not exceed the limits of acid secretion. The concentration of pepsin ((0.67 ± 0.16) mg/ml) was not statistically different from the values of the control group, and the level of glycoproteins ((0.16 ± 0.04) mg/ml) tended to increase by 58.6 %. In patients with stenosis of the gastroduodenal zone, a loss of the ratio of the components of the protective factors of gastric juice was observed against the background of a decrease in the concentration of fucose ((0.59 ± 0.10) mmol/l) by 48.2 % (р < 0.01) and glycosaminoglycans ((0.66 ± 0.06) mmol/l) by 26.4 % (р < 0.05). The concentration of sialic acids ((0.42 ± 0.06) mmol/l) increased by 363.3 % (р < 0.01) compared to the values of the control group.
Conclusions. It was established that in patients with stenosis of the gastroduodenal zone of ulcer genesis, on average, acid secretion was noted with the preserved functional activity of the main and surface epithelial cells, combined with a violation of the ratio of the components of the protective factors of the gastric juice.